5-Amino-1MQ Spray
5-Amino-1MQ Spray is a pre-dissolved, membrane-permeable quinolinium small molecule supplied as a metered solution for laboratories studying nicotinamide N-methyltransferase (NNMT) inhibition without a reconstitution step. Every wholesale lot is verified by reverse-phase HPLC and LC-MS to ≥99.0% purity with batch-specific certificate of analysis documentation. This liquid compound is synthesized and purified for the sole purpose of scientific investigation. This material is supplied strictly for laboratory research purposes and in-vitro scientific testing in controlled developmental or academic settings. It is not designed, approved, or intended under any circumstances for human consumption, clinical application, medical diagnostics, or direct therapeutic administration.
Commercial Order
MOQ: 10 units minimum per spec
5-Amino-1MQ Spray
Access in-depth scientific literature, cellular signaling pathways, and HPLC batch verification for this compound.
Product Specifications
Available Sizes
Wholesale MOQ: 10 Units
Minimum order quantity is 10 units (1 kit).
Contact for Tiered Pricing
Request Pricing
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Clinical Dossier & Technical Digest
Factual reference profile and clinical data specifications.
Metabolic research groups, muscle physiology labs, and NAD+ biology programs are the primary users of 5-Amino-1MQ. A cell biology lab running 3T3-L1 adipocyte differentiation assays will apply it to ask whether suppressing NNMT enzymatic activity alters lipid droplet accumulation and adipogenic gene expression, using intracellular 1-methylnicotinamide by LC-MS/MS as the pharmacodynamic readout. Skeletal muscle groups took a different route after Neelakantan et al. (2019) reported that NNMT inhibition reactivates senescent Pax7+ satellite cells in aged mice, and now use the compound in myoblast and myotube cultures to separate NAD+-dependent from NAD+-independent effects. It also serves as the pharmacological counterpart to NNMT siRNA knockdown: where the Kraus 2014 Nature work silenced the gene, 5-Amino-1MQ inhibits the enzyme, letting a lab test whether both approaches converge on the same phenotype.
Because 5-Amino-1MQ is a permanently charged quinolinium cation rather than a peptide, the analytical pipeline differs from our lyophilized catalog. It runs on reverse-phase HPLC with an ion-pairing mobile phase to give reproducible retention around 4.2 minutes, with UV detection at 254 nm exploiting the aminoquinoline chromophore. LC-MS confirms identity on the m/z 159.1 cation in positive-ion mode. Three degradants get watched: unmethylated 5-aminoquinoline from incomplete alkylation, N-oxide from oxidation of the ring nitrogen, and acetylated amine from solvent carryover. The solution format sidesteps a real problem with the powder, since quinolinium halide salts are hygroscopic and cake in the vial, producing solvation variance between reconstitutions. Sterile filtration at 0.22 µm, nitrogen purge, and amber glass then hold the assayed concentration stable across the stated shelf life.
Structured Procurement Profile & Technical Reference
- Compound Reference 5-Amino-1MQ Spray
- CAS Registry 42464-96-0
- Analytical Grade ≥99.0% High-Purity Research Standard
- Authorized Intended Use Strictly for Laboratory Research Purposes Only
- Supply Availability Pre-Dissolved Spray Bulk Kits (10-unit standard)
- Global Authorized Distributor 99 Purity Wholesale
Analytical Quality Assurance Loop
Every lot of 5-Amino-1MQ Spray undergoes a double-pass chromatography and verification process. We confirm purity by reverse-phase HPLC and identity by exact cation mass using Liquid Chromatography-Mass Spectrometry (LC-MS), alongside metered-solution concentration verification. Finished units are sterile-filtered, nitrogen-purged, and filled into amber glass for long-term molecular stability.
Certificate of Analysis (COA)
Batch-matched HPLC and Mass Spectrometry reports.
5-Amino-1MQ Spray Procurement FAQ
Complete institutional procurement guidance, quality verification protocols, and delivery details for bulk wholesale 5-Amino-1MQ Spray.
What is the verified purity and analytical testing protocol for wholesale 5-Amino-1MQ Spray?
Every wholesale lot of 5-Amino-1MQ Spray is verified to ≥99.0% purity by reverse-phase HPLC with UV detection at 254 nm and confirmed by LC-MS. Each shipment ships with a batch-specific certificate of analysis. Because 5-Amino-1MQ is a quinolinium salt, our screen specifically covers residual 1-methylnicotinamide, unmethylated 5-aminoquinoline starting material, and residual methylating reagent, alongside standard water content and heavy-metal panels.
02Is 5-Amino-1MQ Spray approved for therapeutic use or human consumption?
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Is 5-Amino-1MQ Spray approved for therapeutic use or human consumption?
No. 5-Amino-1MQ Spray is supplied strictly as a Research Use Only (RUO) material for in-vitro laboratory investigation. It is not approved, indicated, or intended for human consumption, medical treatment, diagnostic procedures, veterinary application, or cosmetic use. No NNMT inhibitor has any approved therapeutic indication.
03What is the minimum order quantity for wholesale 5-Amino-1MQ Spray?
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What is the minimum order quantity for wholesale 5-Amino-1MQ Spray?
The minimum order quantity is 10 spray units, which constitutes one standard wholesale kit. 99 Purity Wholesale supplies bulk quantities to research institutions, contract laboratories running NAD+ and metabolic assay panels, and distribution brands. We do not fulfill retail or single-unit inquiries.
04What physical form is wholesale 5-Amino-1MQ Spray supplied in?
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What physical form is wholesale 5-Amino-1MQ Spray supplied in?
5-Amino-1MQ Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 50 mg per unit. The amber glass matters here: the aminoquinolinium chromophore absorbs in the near-UV and photodegrades under ambient light. Headspace is nitrogen-purged before capping to limit oxidation of the free aromatic amine, and no reconstitution step is required before use.
05What are the recommended storage conditions and stability limits for 5-Amino-1MQ Spray?
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What are the recommended storage conditions and stability limits for 5-Amino-1MQ Spray?
Store 5-Amino-1MQ Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 60 days. Do not freeze: the solvent system can crystallize and repeated freeze-thaw cycles concentrate the quinolinium salt at the ice boundary, which shifts the assayed concentration. Brief excursions to 15°C to 25°C (59°F to 77°F) during transit are tolerated.
06What is the primary molecular target or mechanism of action researched for 5-Amino-1MQ Spray?
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What is the primary molecular target or mechanism of action researched for 5-Amino-1MQ Spray?
5-Amino-1MQ is a substrate-competitive inhibitor of nicotinamide N-methyltransferase (NNMT, EC 2.1.1.1, UniProt P40261). NNMT transfers a methyl group from S-adenosyl-L-methionine to nicotinamide, producing 1-methylnicotinamide and S-adenosylhomocysteine. By occupying the nicotinamide pocket, 5-Amino-1MQ closes that exit route, so free nicotinamide is instead routed through NAMPT and NMNAT1/2/3 back into NAD+ (KEGG map00760). The resulting rise in the NAD+/NADH ratio increases flux through SIRT1 and SIRT3 and the LKB1/AMPK axis, with PGC-1α deacetylation as a downstream readout. This is enzyme inhibition, not receptor agonism, and it also shifts the cellular SAM/SAH methyl-donor ratio.
07Can I request custom concentrations, vial sizes, or formulations for wholesale 5-Amino-1MQ Spray?
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Can I request custom concentrations, vial sizes, or formulations for wholesale 5-Amino-1MQ Spray?
Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary NAD+ pathway research compounds. Contact our corporate sales desk with your target concentration and unit count to scope the run.
08How is wholesale 5-Amino-1MQ Spray packaged and shipped to preserve compound integrity?
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How is wholesale 5-Amino-1MQ Spray packaged and shipped to preserve compound integrity?
Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the photolabile aminoquinolinium core against oxidation. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.
Related Research Compounds
5-AMINO-1MQ
Research-grade compound intended strictly for laboratory, analytical, and in-vitro research applications. Not for human consumption, therapeutic use, veterinary use, or diagnostic procedures.
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