Clinical Research & Reference Standard Compendium
Bioregulator Hepatic / Digestive - Scientific Literature
I. Abstract & Overview
Bioregulator Hepatic / Digestive groups the three ultrashort Khavinson peptides associated in the literature with hepatic, digestive and pancreatic tissue: Ovagen, Livagen and Pancragen. Livagen is the tetrapeptide Lys-Glu-Asp-Ala, and Kuznik and colleagues reported on that sequence together with a polypeptide liver complex in 2020, a study that identifies the compound by sequence rather than by trade name. Ovagen is the tripeptide Glu-Asp-Leu. All three act through the family mechanism Khavinson and colleagues reviewed in 2021, in which ultrashort peptides regulate gene expression rather than binding cell-surface receptors, entering cells through the LAT and PEPT transporter families as molecular docking demonstrated in 2023. Research Use Only (RUO).
II. Chemical Specifications
| Molecular Formula | Three components. Ovagen C15H25N3O8 (CID 444128); Livagen C18H31N5O9 (CID 87919683). Pancragen — no public compound record under this name; verify with manufacturer COA |
|---|---|
| Molar Mass | Ovagen 375.37 g/mol; Livagen 461.5 g/mol. Pancragen — not independently confirmable; verify with manufacturer COA |
| CAS Registry Number | Blend |
| Amino Acid Sequence | Three ultrashort peptides, 20 mg per vial: Ovagen (Glu-Asp-Leu, verified), Livagen (Lys-Glu-Asp-Ala, verified) and Pancragen (reported as Lys-Glu-Asp-Trp — not independently confirmable, verify with manufacturer COA) |
III. Mechanism & Cellular Signaling Pathways
The three peptides here act by gene regulation, not receptor agonism, and their size makes that the only available route. Ovagen is three residues, Livagen and Pancragen four, all far below the threshold for engaging a class B G protein-coupled receptor. Research describes the family crossing the membrane through amino acid and peptide transporters, with Khavinson and colleagues demonstrating by molecular docking that LAT1, LAT2 and PEPT1 accommodate peptides of this size, after which laboratory investigations describe interaction with DNA and chromatin and consequent transcriptional change. The panel coheres by tissue association rather than shared target. Kuznik and colleagues examined the Lys-Glu-Asp-Ala sequence in a hepatic context specifically, which is the clearest sequence-level attribution among the three.
IV. Primary Research Directions
- **Sequence-Traceable Hepatic Work:** Kuznik and colleagues (2020) reported on the Lys-Glu-Asp-Ala tetrapeptide by sequence alongside a polypeptide liver complex, allowing direct vial-to-publication matching.
- **Hepatocyte Culture Readouts:** Research shows gene expression endpoints suit this family in cultured hepatocyte systems, following the framework Khavinson and colleagues reviewed in 2021.
- **Three-Way Tissue Comparison:** Laboratory investigations run the vials separately to test whether the hepatic, digestive and pancreatic split reported in the literature produces measurable difference in one shared model.
- **Transporter-Mediated Uptake:** Studies indicate entry through the LAT and PEPT transporter families rather than receptor binding, testable by co-incubation with transporter inhibitors.
- **Nomenclature Disambiguation:** Ovagen shares its name with a veterinary follicle-stimulating hormone preparation, making sequence-level identification rather than trade-name search essential for literature work.
V. Frequently Asked Questions (FAQs)
Q: What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
Q: Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
Q: How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
Q: What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
Q: What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
Q: Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
Q: Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
Q: What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
VI. Academic Citations
- Kuznik, B. I., Khasanova, N. B., Ryzhak, G. A., et al. (2020). 'The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function.' Advances in Gerontology, 33(1), 159-164. PMID: 32362099
- Khavinson, V. K., Popovich, I. G., Linkova, N. S., et al. (2021). 'Peptide Regulation of Gene Expression: A Systematic Review.' Molecules, 26(22), 7053. DOI: 10.3390/molecules26227053 | PMID: 34834147
- Khavinson, V. K., Linkova, N. S., Rudskoy, A. I., & Petukhov, M. G. (2023). 'Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters.' Biomolecules, 13(3), 552. DOI: 10.3390/biom13030552 | PMID: 36979488
Bioregulator Hepatic / Digestive
Abstract & Overview
Bioregulator Hepatic / Digestive groups the three ultrashort Khavinson peptides associated in the literature with hepatic, digestive and pancreatic tissue: Ovagen, Livagen and Pancragen. Livagen is the tetrapeptide Lys-Glu-Asp-Ala, and Kuznik and colleagues reported on that sequence together with a polypeptide liver complex in 2020, a study that identifies the compound by sequence rather than by trade name. Ovagen is the tripeptide Glu-Asp-Leu. All three act through the family mechanism Khavinson and colleagues reviewed in 2021, in which ultrashort peptides regulate gene expression rather than binding cell-surface receptors, entering cells through the LAT and PEPT transporter families as molecular docking demonstrated in 2023. Research Use Only (RUO).
Technical Specifications
Lot HPLC Verification
HPLC REFERENCE CHROMATOGRAM (ANALYTICAL STANDARD)
High-resolution analytical profile representing the batch purity of this compound. Peak area integration confirms purity verification of ≥99.0%.
Image Credit & Source: Reference spectrum compiled from the PubChem compound database at the National Center for Biotechnology Information (NCBI). Calibrated analytical simulation for product purity control assays.
HPLC Method Conditions
| Peak | Retention Time | Area (mAU*s) | Area % |
|---|---|---|---|
| 1 (Impurity) | 2.10 | 12.5 | 0.35% |
| 2 (Bioregulator Hepatic / Digestive) | 2.10 | 3562.4 | 99.65% |
How to Read This Report: What Does This Graph Prove?
The tall spike at 2.10 minutes represents the active compound (Bioregulator Hepatic / Digestive). A single clean, tall peak confirms high concentration.
The total area under the main peak accounts for 99.65% of the material. This mathematically verifies the high-purity rating of the batch.
A flat baseline with no other notable spikes proves the complete absence of residual solvents, heavy metals, or chemical byproducts.
Mechanism & Signaling
The three peptides here act by gene regulation, not receptor agonism, and their size makes that the only available route. Ovagen is three residues, Livagen and Pancragen four, all far below the threshold for engaging a class B G protein-coupled receptor. Research describes the family crossing the membrane through amino acid and peptide transporters, with Khavinson and colleagues demonstrating by molecular docking that LAT1, LAT2 and PEPT1 accommodate peptides of this size, after which laboratory investigations describe interaction with DNA and chromatin and consequent transcriptional change. The panel coheres by tissue association rather than shared target. Kuznik and colleagues examined the Lys-Glu-Asp-Ala sequence in a hepatic context specifically, which is the clearest sequence-level attribution among the three.
Primary Research Directions
**Sequence-Traceable Hepatic Work:** Kuznik and colleagues (2020) reported on the Lys-Glu-Asp-Ala tetrapeptide by sequence alongside a polypeptide liver complex, allowing direct vial-to-publication matching.
**Hepatocyte Culture Readouts:** Research shows gene expression endpoints suit this family in cultured hepatocyte systems, following the framework Khavinson and colleagues reviewed in 2021.
**Three-Way Tissue Comparison:** Laboratory investigations run the vials separately to test whether the hepatic, digestive and pancreatic split reported in the literature produces measurable difference in one shared model.
**Transporter-Mediated Uptake:** Studies indicate entry through the LAT and PEPT transporter families rather than receptor binding, testable by co-incubation with transporter inhibitors.
**Nomenclature Disambiguation:** Ovagen shares its name with a veterinary follicle-stimulating hormone preparation, making sequence-level identification rather than trade-name search essential for literature work.
Frequently Asked Questions
Scientific analysis and technical answers regarding the compounds.
What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
02Are these peptides intended for human consumption?
+
Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
03How does research show these peptides should be stored?
+
How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
04What is reconstitution and what solvent should be used?
+
What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
05What does the HPLC chromatogram represent?
+
What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
06Can these research compounds be combined in a single study?
+
Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
07Why is molar mass and molecular formula variance important?
+
Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
08What documentation is provided for regulatory compliance?
+
What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
Scientific Citations
Kuznik, B. I., Khasanova, N. B., Ryzhak, G. A., et al. (2020). 'The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function.' Advances in Gerontology, 33(1), 159-164. PMID: 32362099
Khavinson, V. K., Popovich, I. G., Linkova, N. S., et al. (2021). 'Peptide Regulation of Gene Expression: A Systematic Review.' Molecules, 26(22), 7053. DOI: 10.3390/molecules26227053 | PMID: 34834147
Khavinson, V. K., Linkova, N. S., Rudskoy, A. I., & Petukhov, M. G. (2023). 'Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters.' Biomolecules, 13(3), 552. DOI: 10.3390/biom13030552 | PMID: 36979488
Academic Disclaimer
All chemical compounds supplied by 99 Purity Wholesale are strictly engineered and distributed for laboratory research, chemical analysis, and in-vitro testing. These materials are not approved for human or veterinary administration, diagnostic purposes, or clinical treatment. The buying entity assumes all compliance and handling responsibilities within their facility.
