Clinical Research & Reference Standard Compendium
Body Composition Kit - Scientific Literature
I. Abstract & Overview
Body Composition Kit supplies Tesamorelin (10 mg), Ipamorelin (5 mg) and AOD9604 (5 mg) as three separately labelled lyophilized vials. Two components act at the pituitary through unrelated receptor superfamilies — a class B GHRH receptor and a class A ghrelin receptor — while the third acts at adipose tissue independent of both, giving three mechanistically distinct arms plus combinations from a single tray. Molecular weights span roughly sevenfold across the three vials. Supplied for Research Use Only.
II. Chemical Specifications
| Molecular Formula | Blend — no single formula applies; Tesamorelin C221H366N72O67S, Ipamorelin C38H49N9O5, AOD9604 C78H123N23O23S2 |
|---|---|
| Molar Mass | Tesamorelin 5135.9 g/mol; Ipamorelin 711.9 g/mol; AOD9604 1815.1 g/mol — an approximately sevenfold spread |
| CAS Registry Number | Blend |
| Amino Acid Sequence | Tesamorelin trans-3-hexenoyl-GHRH(1-44) amide; Ipamorelin Aib-His-D-2-Nal-D-Phe-Lys-NH2; AOD9604 Tyr-substituted hGH(176-191) |
III. Mechanism & Cellular Signaling Pathways
Tesamorelin is a growth hormone releasing factor analog stabilised at the amino terminus by a trans-3-hexenoyl group, engaging the class B GHRH receptor and its associated adenylyl cyclase signaling. Ipamorelin is a selective pentapeptide agonist at the ghrelin receptor GHS-R1a, a class A receptor coupling through a phospholipase C route; its selectivity is the reason it is studied where earlier secretagogues produced off-target endocrine effects. AOD9604 corresponds to the carboxy-terminal lipolytic domain of growth hormone with a tyrosine substituted at the first position, and published work reports lipolytic activity persisting in beta-3 adrenergic receptor knockout animals.
IV. Primary Research Directions
- Two receptor superfamilies plus one receptor-independent adipose mechanism in a single tray, yielding three distinct arms and a combination arm without cross-supplier sourcing
- Tesamorelin at a 10 mg fill — double the other two components — reflecting that it is the one component with an approved-product comparator literature at defined concentrations
- AOD9604 released on LC-MS with the observed mass printed, so the 16 dalton separation from the unmodified 176-191 fragment is documented rather than assumed
- Tesamorelin released by peptide mapping rather than intact mass, appropriate to a 44-residue chain with an acylated amino terminus
- Sevenfold molecular weight span disclosed on the tray so molar calculations are not carried across vials by mistake
V. Frequently Asked Questions (FAQs)
Q: What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
Q: Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
Q: How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
Q: What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
Q: What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
Q: Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
Q: Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
Q: What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
VI. Academic Citations
- Ferdinandi, E. S., Brazeau, P., High, K., et al. (2007). 'Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue.' Basic & Clinical Pharmacology & Toxicology, 100(1), 49-58. DOI: 10.1111/j.1742-7843.2007.00008.x | PMID: 17214611
- Raun, K., Hansen, B. S., Johansen, N. L., et al. (1998). 'Ipamorelin, the first selective growth hormone secretagogue.' European Journal of Endocrinology, 139(5), 552-561. DOI: 10.1530/eje.0.1390552 | PMID: 9849822
- Heffernan, M., Summers, R. J., Thorburn, A., et al. (2001). 'The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta-3 AR knock-out mice.' Endocrinology, 142(12), 5182-5189. DOI: 10.1210/endo.142.12.8522 | PMID: 11713213
Body Composition Kit
Abstract & Overview
Body Composition Kit supplies Tesamorelin (10 mg), Ipamorelin (5 mg) and AOD9604 (5 mg) as three separately labelled lyophilized vials. Two components act at the pituitary through unrelated receptor superfamilies — a class B GHRH receptor and a class A ghrelin receptor — while the third acts at adipose tissue independent of both, giving three mechanistically distinct arms plus combinations from a single tray. Molecular weights span roughly sevenfold across the three vials. Supplied for Research Use Only.
Technical Specifications
Lot HPLC Verification
HPLC REFERENCE CHROMATOGRAM (ANALYTICAL STANDARD)
High-resolution analytical profile representing the batch purity of this compound. Peak area integration confirms purity verification of ≥99.0%.
Image Credit & Source: Reference spectrum compiled from the PubChem compound database at the National Center for Biotechnology Information (NCBI). Calibrated analytical simulation for product purity control assays.
HPLC Method Conditions
| Peak | Retention Time | Area (mAU*s) | Area % |
|---|---|---|---|
| 1 (Impurity) | 2.10 | 12.5 | 0.35% |
| 2 (Body Composition Kit) | 7.60 | 3562.4 | 99.65% |
How to Read This Report: What Does This Graph Prove?
The tall spike at 7.60 minutes represents the active compound (Body Composition Kit). A single clean, tall peak confirms high concentration.
The total area under the main peak accounts for 99.65% of the material. This mathematically verifies the high-purity rating of the batch.
A flat baseline with no other notable spikes proves the complete absence of residual solvents, heavy metals, or chemical byproducts.
Mechanism & Signaling
Tesamorelin is a growth hormone releasing factor analog stabilised at the amino terminus by a trans-3-hexenoyl group, engaging the class B GHRH receptor and its associated adenylyl cyclase signaling. Ipamorelin is a selective pentapeptide agonist at the ghrelin receptor GHS-R1a, a class A receptor coupling through a phospholipase C route; its selectivity is the reason it is studied where earlier secretagogues produced off-target endocrine effects. AOD9604 corresponds to the carboxy-terminal lipolytic domain of growth hormone with a tyrosine substituted at the first position, and published work reports lipolytic activity persisting in beta-3 adrenergic receptor knockout animals.
Primary Research Directions
Two receptor superfamilies plus one receptor-independent adipose mechanism in a single tray, yielding three distinct arms and a combination arm without cross-supplier sourcing
Tesamorelin at a 10 mg fill — double the other two components — reflecting that it is the one component with an approved-product comparator literature at defined concentrations
AOD9604 released on LC-MS with the observed mass printed, so the 16 dalton separation from the unmodified 176-191 fragment is documented rather than assumed
Tesamorelin released by peptide mapping rather than intact mass, appropriate to a 44-residue chain with an acylated amino terminus
Sevenfold molecular weight span disclosed on the tray so molar calculations are not carried across vials by mistake
Frequently Asked Questions
Scientific analysis and technical answers regarding the compounds.
What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
02Are these peptides intended for human consumption?
+
Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
03How does research show these peptides should be stored?
+
How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
04What is reconstitution and what solvent should be used?
+
What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
05What does the HPLC chromatogram represent?
+
What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
06Can these research compounds be combined in a single study?
+
Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
07Why is molar mass and molecular formula variance important?
+
Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
08What documentation is provided for regulatory compliance?
+
What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
Scientific Citations
Ferdinandi, E. S., Brazeau, P., High, K., et al. (2007). 'Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue.' Basic & Clinical Pharmacology & Toxicology, 100(1), 49-58. DOI: 10.1111/j.1742-7843.2007.00008.x | PMID: 17214611
Raun, K., Hansen, B. S., Johansen, N. L., et al. (1998). 'Ipamorelin, the first selective growth hormone secretagogue.' European Journal of Endocrinology, 139(5), 552-561. DOI: 10.1530/eje.0.1390552 | PMID: 9849822
Heffernan, M., Summers, R. J., Thorburn, A., et al. (2001). 'The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta-3 AR knock-out mice.' Endocrinology, 142(12), 5182-5189. DOI: 10.1210/endo.142.12.8522 | PMID: 11713213
Academic Disclaimer
All chemical compounds supplied by 99 Purity Wholesale are strictly engineered and distributed for laboratory research, chemical analysis, and in-vitro testing. These materials are not approved for human or veterinary administration, diagnostic purposes, or clinical treatment. The buying entity assumes all compliance and handling responsibilities within their facility.
