H-Frag Spray

H-Frag Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 5 mg per unit. Unlike most short peptides in this catalog, this sequence contains two cysteines that form an internal disulfide loop, so the buffer is chosen to keep that bond intact rather than simply to maximise solubility. Headspace is nitrogen-purged before capping to prevent oxidation of free thiols, and no reconstitution step is required.

Store H-Frag Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Avoid freeze-thaw cycling and avoid contact with reducing agents. The internal disulfide bond is the structural feature that distinguishes this fragment from most short peptides, and reduction opens the loop into a linear peptide with the same residue composition but different conformation. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

H-Frag corresponds to residues 176 to 191 of human growth hormone, the segment identified as the lipolytic domain. Its defining property is what it does not do: this fragment acts on fat metabolism without engaging the growth hormone receptor, so it does not drive hepatic IGF-1 production or produce the glucose handling changes the full hormone causes. Ng and colleagues characterized the synthetic lipolytic domain and reported effects on lipid metabolism in fatty rodent models, and Heffernan and colleagues compared the fragment against full growth hormone directly. Research indicates the mechanism involves modulation of adipocyte lipolytic and lipogenic enzyme activity rather than classical receptor agonism. The sequence carries an internal disulfide loop that most short catalog peptides lack.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary metabolic research compounds such as AOD9604. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the internal disulfide loop and the two cysteine residues. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.