LL-37 Spray

LL-37 Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 1 mg per unit. The lower unit strength reflects how this peptide is actually used, since antimicrobial assays work at low micromolar concentrations rather than the milligram loads metabolic compounds require. The pre-dissolved format also sidesteps the adsorption losses that cationic peptides suffer during manual reconstitution. Headspace is nitrogen-purged before capping.

Store LL-37 Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Avoid freeze-thaw cycling and avoid transferring between containers unnecessarily, because each transfer loses cationic peptide to surface adsorption and quietly lowers the working concentration. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

LL-37 is the only cathelicidin peptide humans produce, released from a precursor protein by enzymatic cleavage, and it works through two distinct mechanisms. The first is physical rather than biochemical: the peptide is unstructured in aqueous solution but folds into an amphipathic helix on contact with anionic bacterial membranes, then disrupts them through a carpet-like permeabilization. Its strong net positive charge is what confers selectivity, since bacterial membranes are anionic while mammalian membranes are largely neutral at the surface. The second mechanism is host signaling: research shows LL-37 engages formyl peptide receptor 2 on leukocytes, driving chemotaxis and activation, and it also binds and neutralizes bacterial lipopolysaccharide directly.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary immune research compounds such as KPV. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the highly cationic backbone against surface adsorption. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.