MOTS-c Spray

MOTS-c Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 10 mg or 40 mg per unit. At 16 residues it dissolves readily in aqueous buffer, and the pre-dissolved format is particularly useful here because the two methionine residues begin oxidizing on contact with air during any manual reconstitution step. Headspace is nitrogen-purged before capping, and no reconstitution is required.

Store MOTS-c Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Minimize air exposure and avoid freeze-thaw cycling: with two methionines in a short sequence, oxidation is the limiting stability factor rather than aggregation, and each cycle increases headspace contact. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

MOTS-c is unusual before you even reach its mechanism: it is encoded within mitochondrial DNA rather than the nuclear genome, one of only a handful of peptides with that origin. Lee and colleagues reported in 2015 that it acts on the folate and methionine cycle, and that the resulting accumulation of an intermediate called AICAR activates AMP-activated protein kinase, shifting cells toward glucose utilization. Kim and colleagues later found a second, separate role. Under metabolic stress the peptide translocates into the nucleus, where it associates with stress-responsive transcription factors and regulates antioxidant and metabolic gene programs. Acting in both the cytosol and the nucleus is rare for a peptide of this size, and it is why MOTS-c is studied differently from receptor ligands.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary mitochondrial research compounds such as SS-31. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the two oxidation-prone methionine residues. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.