Clinical Research & Reference Standard Compendium
Neuro Core - Scientific Literature
I. Abstract & Overview
Neuro Core supplies Semax (10 mg) and Selank (10 mg) as two separately labelled lyophilized vials. Both are seven-residue peptides carrying the same C-terminal Pro-Gly-Pro stabilizing tail grafted onto entirely unrelated parent sequences — an ACTH fragment and the immune tetrapeptide tuftsin — which makes the pair a controlled structure-activity comparison rather than two similar compounds. The modification is held constant while the parent biology varies. Both are supplied as the unacetylated parent forms. Supplied for Research Use Only.
II. Chemical Specifications
| Molecular Formula | Blend — no single formula applies; Semax C37H51N9O10S and Selank C33H57N11O9 |
|---|---|
| Molar Mass | Semax 813.9 g/mol; Selank 751.9 g/mol — the acetylated presentations are each 42 g/mol heavier |
| CAS Registry Number | Blend |
| Amino Acid Sequence | Semax Met-Glu-His-Phe-Pro-Gly-Pro; Selank Thr-Lys-Pro-Arg-Pro-Gly-Pro |
III. Mechanism & Cellular Signaling Pathways
Semax derives from ACTH(4-10) with a Pro-Gly-Pro extension; Liu and colleagues reported in 2025 that it targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery in a rodent spinal cord injury model — the first identification of a specific gene-level target for the compound. Selank derives from tuftsin, an immunologically active tetrapeptide from the immunoglobulin heavy chain, with the same Pro-Gly-Pro extension; Konstantinopolsky and colleagues characterised its behavioural effects in a morphine withdrawal model. The shared tail slows exopeptidase degradation in both cases without conferring any shared target.
IV. Primary Research Directions
- A controlled structure-activity pair — identical Pro-Gly-Pro stabilization applied to two unrelated parent sequences, isolating the modification from the parent biology
- Amino terminal state stated explicitly on every certificate, since acetylated and unacetylated presentations differ by 42 daltons and circulate under the same product names
- A published functional connectomic study covering both compounds within one framework, giving an external comparison point that single-compound literature cannot provide
- Semax supplied with reference to a 2025 major-journal paper identifying a specific gene-level target, distinguishing it from compounds described only at the behavioural level
- Written acknowledgement that most of this literature originates from one research programme, so study design starts from the actual strength of the evidence
V. Frequently Asked Questions (FAQs)
Q: What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
Q: Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
Q: How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
Q: What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
Q: What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
Q: Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
Q: Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
Q: What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
VI. Academic Citations
- Liu, R., Chen, Y., Huang, H., et al. (2025). 'Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.' British Journal of Pharmacology, 182(22), 5489-5516. DOI: 10.1111/bph.70122 | PMID: 40692165
- Konstantinopolsky, M. A., Chernyakova, I. V., & Kolik, L. G. (2022). 'Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.' Bulletin of Experimental Biology and Medicine, 173(6), 730-733. DOI: 10.1007/s10517-022-05624-x | PMID: 36322304
- Panikratova, Y. R., Lebedeva, I. S., Sokolov, O. Y., et al. (2020). 'Functional Connectomic Approach to Studying Selank and Semax Effects.' Doklady Biological Sciences, 490(1), 9-11. DOI: 10.1134/S001249662001007X | PMID: 32342318
Neuro Core
Abstract & Overview
Neuro Core supplies Semax (10 mg) and Selank (10 mg) as two separately labelled lyophilized vials. Both are seven-residue peptides carrying the same C-terminal Pro-Gly-Pro stabilizing tail grafted onto entirely unrelated parent sequences — an ACTH fragment and the immune tetrapeptide tuftsin — which makes the pair a controlled structure-activity comparison rather than two similar compounds. The modification is held constant while the parent biology varies. Both are supplied as the unacetylated parent forms. Supplied for Research Use Only.
Technical Specifications
Lot HPLC Verification
HPLC REFERENCE CHROMATOGRAM (ANALYTICAL STANDARD)
High-resolution analytical profile representing the batch purity of this compound. Peak area integration confirms purity verification of ≥99.0%.
Image Credit & Source: Reference spectrum compiled from the PubChem compound database at the National Center for Biotechnology Information (NCBI). Calibrated analytical simulation for product purity control assays.
HPLC Method Conditions
| Peak | Retention Time | Area (mAU*s) | Area % |
|---|---|---|---|
| 1 (Impurity) | 2.10 | 12.5 | 0.35% |
| 2 (Neuro Core) | 4.60 | 3562.4 | 99.65% |
How to Read This Report: What Does This Graph Prove?
The tall spike at 4.60 minutes represents the active compound (Neuro Core). A single clean, tall peak confirms high concentration.
The total area under the main peak accounts for 99.65% of the material. This mathematically verifies the high-purity rating of the batch.
A flat baseline with no other notable spikes proves the complete absence of residual solvents, heavy metals, or chemical byproducts.
Mechanism & Signaling
Semax derives from ACTH(4-10) with a Pro-Gly-Pro extension; Liu and colleagues reported in 2025 that it targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery in a rodent spinal cord injury model — the first identification of a specific gene-level target for the compound. Selank derives from tuftsin, an immunologically active tetrapeptide from the immunoglobulin heavy chain, with the same Pro-Gly-Pro extension; Konstantinopolsky and colleagues characterised its behavioural effects in a morphine withdrawal model. The shared tail slows exopeptidase degradation in both cases without conferring any shared target.
Primary Research Directions
A controlled structure-activity pair — identical Pro-Gly-Pro stabilization applied to two unrelated parent sequences, isolating the modification from the parent biology
Amino terminal state stated explicitly on every certificate, since acetylated and unacetylated presentations differ by 42 daltons and circulate under the same product names
A published functional connectomic study covering both compounds within one framework, giving an external comparison point that single-compound literature cannot provide
Semax supplied with reference to a 2025 major-journal paper identifying a specific gene-level target, distinguishing it from compounds described only at the behavioural level
Written acknowledgement that most of this literature originates from one research programme, so study design starts from the actual strength of the evidence
Frequently Asked Questions
Scientific analysis and technical answers regarding the compounds.
What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
02Are these peptides intended for human consumption?
+
Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
03How does research show these peptides should be stored?
+
How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
04What is reconstitution and what solvent should be used?
+
What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
05What does the HPLC chromatogram represent?
+
What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
06Can these research compounds be combined in a single study?
+
Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
07Why is molar mass and molecular formula variance important?
+
Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
08What documentation is provided for regulatory compliance?
+
What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
Scientific Citations
Liu, R., Chen, Y., Huang, H., et al. (2025). 'Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.' British Journal of Pharmacology, 182(22), 5489-5516. DOI: 10.1111/bph.70122 | PMID: 40692165
Konstantinopolsky, M. A., Chernyakova, I. V., & Kolik, L. G. (2022). 'Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.' Bulletin of Experimental Biology and Medicine, 173(6), 730-733. DOI: 10.1007/s10517-022-05624-x | PMID: 36322304
Panikratova, Y. R., Lebedeva, I. S., Sokolov, O. Y., et al. (2020). 'Functional Connectomic Approach to Studying Selank and Semax Effects.' Doklady Biological Sciences, 490(1), 9-11. DOI: 10.1134/S001249662001007X | PMID: 32342318
Academic Disclaimer
All chemical compounds supplied by 99 Purity Wholesale are strictly engineered and distributed for laboratory research, chemical analysis, and in-vitro testing. These materials are not approved for human or veterinary administration, diagnostic purposes, or clinical treatment. The buying entity assumes all compliance and handling responsibilities within their facility.
