Clinical Research & Reference Standard Compendium
Recovery, Sleep & Stress - Scientific Literature
I. Abstract & Overview
Recovery, Sleep & Stress supplies DSIP (5 mg), Selank (10 mg) and Oxytocin (10 mg) as three separately labelled lyophilized vials. The three occupy markedly different levels of mechanistic certainty: oxytocin acts at a fully characterised class A receptor with a resolved signaling map, Selank has defined study endpoints without a single named receptor, and DSIP has had no identified receptor since its isolation in 1977. Oxytocin is the only cyclic component, closed by a structural disulfide bridge. Supplied for Research Use Only.
II. Chemical Specifications
| Molecular Formula | Blend — no single formula applies; DSIP C35H48N10O15, Selank C33H57N11O9, Oxytocin C43H66N12O12S2 |
|---|---|
| Molar Mass | DSIP 848.8 g/mol; Selank 751.9 g/mol; Oxytocin 1007.2 g/mol as the disulfide-closed cyclic form |
| CAS Registry Number | Blend |
| Amino Acid Sequence | DSIP Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu; Selank Thr-Lys-Pro-Arg-Pro-Gly-Pro; Oxytocin Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 with a disulfide bridge between residues 1 and 6 |
III. Mechanism & Cellular Signaling Pathways
Oxytocin binds the oxytocin receptor, a class A G protein-coupled receptor whose signaling Jurek and Neumann mapped comprehensively from intracellular cascade through to behavioural output; its nine-residue sequence is closed into a ring by a disulfide bridge between cysteines at positions one and six. Selank is a tuftsin analog carrying a Pro-Gly-Pro extension, studied against GABAergic and cytokine endpoints, with Konstantinopolsky and colleagues reporting behavioural effects in a withdrawal model. DSIP was characterised by Schoenenberger and Monnier in 1977 as an electroencephalographic sleep-inducing factor; no receptor has been identified in the decades since, and Kovalzon and Strekalova's review title calls it a still unresolved riddle.
IV. Primary Research Directions
- A deliberate span from a fully characterised receptor system to one uncharacterised for nearly fifty years, letting an experiment carry its own internal reference point
- Oxytocin released with explicit disulfide integrity confirmation, since a reduced linear batch shares the amino acid composition and passes a purity assay
- Written disclosure that DSIP has no identified receptor after five decades, framing a DSIP arm as exploratory rather than confirmatory work
- The only tray in this catalog pairing a cyclic disulfide-closed peptide with two linear chains, giving directly comparable handling behaviour
- Oxytocin’s comprehensively mapped receptor signaling available as an external positive control for assays where the other two components have none
V. Frequently Asked Questions (FAQs)
Q: What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
Q: Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
Q: How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
Q: What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
Q: What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
Q: Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
Q: Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
Q: What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
VI. Academic Citations
- Jurek, B., & Neumann, I. D. (2018). 'The Oxytocin Receptor: From Intracellular Signaling to Behavior.' Physiological Reviews, 98(3), 1805-1908. DOI: 10.1152/physrev.00031.2017 | PMID: 29897293
- Kovalzon, V. M., & Strekalova, T. V. (2006). 'Delta sleep-inducing peptide (DSIP): a still unresolved riddle.' Journal of Neurochemistry, 97(2), 303-309. DOI: 10.1111/j.1471-4159.2006.03693.x | PMID: 16539679
- Konstantinopolsky, M. A., Chernyakova, I. V., & Kolik, L. G. (2022). 'Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.' Bulletin of Experimental Biology and Medicine, 173(6), 730-733. DOI: 10.1007/s10517-022-05624-x | PMID: 36322304
Recovery, Sleep & Stress
Abstract & Overview
Recovery, Sleep & Stress supplies DSIP (5 mg), Selank (10 mg) and Oxytocin (10 mg) as three separately labelled lyophilized vials. The three occupy markedly different levels of mechanistic certainty: oxytocin acts at a fully characterised class A receptor with a resolved signaling map, Selank has defined study endpoints without a single named receptor, and DSIP has had no identified receptor since its isolation in 1977. Oxytocin is the only cyclic component, closed by a structural disulfide bridge. Supplied for Research Use Only.
Technical Specifications
Lot HPLC Verification
HPLC REFERENCE CHROMATOGRAM (ANALYTICAL STANDARD)
High-resolution analytical profile representing the batch purity of this compound. Peak area integration confirms purity verification of ≥99.0%.
Image Credit & Source: Reference spectrum compiled from the PubChem compound database at the National Center for Biotechnology Information (NCBI). Calibrated analytical simulation for product purity control assays.
HPLC Method Conditions
| Peak | Retention Time | Area (mAU*s) | Area % |
|---|---|---|---|
| 1 (Impurity) | 2.10 | 12.5 | 0.35% |
| 2 (Recovery, Sleep & Stress) | 3.40 | 3562.4 | 99.65% |
How to Read This Report: What Does This Graph Prove?
The tall spike at 3.40 minutes represents the active compound (Recovery, Sleep & Stress). A single clean, tall peak confirms high concentration.
The total area under the main peak accounts for 99.65% of the material. This mathematically verifies the high-purity rating of the batch.
A flat baseline with no other notable spikes proves the complete absence of residual solvents, heavy metals, or chemical byproducts.
Mechanism & Signaling
Oxytocin binds the oxytocin receptor, a class A G protein-coupled receptor whose signaling Jurek and Neumann mapped comprehensively from intracellular cascade through to behavioural output; its nine-residue sequence is closed into a ring by a disulfide bridge between cysteines at positions one and six. Selank is a tuftsin analog carrying a Pro-Gly-Pro extension, studied against GABAergic and cytokine endpoints, with Konstantinopolsky and colleagues reporting behavioural effects in a withdrawal model. DSIP was characterised by Schoenenberger and Monnier in 1977 as an electroencephalographic sleep-inducing factor; no receptor has been identified in the decades since, and Kovalzon and Strekalova's review title calls it a still unresolved riddle.
Primary Research Directions
A deliberate span from a fully characterised receptor system to one uncharacterised for nearly fifty years, letting an experiment carry its own internal reference point
Oxytocin released with explicit disulfide integrity confirmation, since a reduced linear batch shares the amino acid composition and passes a purity assay
Written disclosure that DSIP has no identified receptor after five decades, framing a DSIP arm as exploratory rather than confirmatory work
The only tray in this catalog pairing a cyclic disulfide-closed peptide with two linear chains, giving directly comparable handling behaviour
Oxytocin’s comprehensively mapped receptor signaling available as an external positive control for assays where the other two components have none
Frequently Asked Questions
Scientific analysis and technical answers regarding the compounds.
What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
02Are these peptides intended for human consumption?
+
Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
03How does research show these peptides should be stored?
+
How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
04What is reconstitution and what solvent should be used?
+
What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
05What does the HPLC chromatogram represent?
+
What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
06Can these research compounds be combined in a single study?
+
Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
07Why is molar mass and molecular formula variance important?
+
Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
08What documentation is provided for regulatory compliance?
+
What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
Scientific Citations
Jurek, B., & Neumann, I. D. (2018). 'The Oxytocin Receptor: From Intracellular Signaling to Behavior.' Physiological Reviews, 98(3), 1805-1908. DOI: 10.1152/physrev.00031.2017 | PMID: 29897293
Kovalzon, V. M., & Strekalova, T. V. (2006). 'Delta sleep-inducing peptide (DSIP): a still unresolved riddle.' Journal of Neurochemistry, 97(2), 303-309. DOI: 10.1111/j.1471-4159.2006.03693.x | PMID: 16539679
Konstantinopolsky, M. A., Chernyakova, I. V., & Kolik, L. G. (2022). 'Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.' Bulletin of Experimental Biology and Medicine, 173(6), 730-733. DOI: 10.1007/s10517-022-05624-x | PMID: 36322304
Academic Disclaimer
All chemical compounds supplied by 99 Purity Wholesale are strictly engineered and distributed for laboratory research, chemical analysis, and in-vitro testing. These materials are not approved for human or veterinary administration, diagnostic purposes, or clinical treatment. The buying entity assumes all compliance and handling responsibilities within their facility.
