Semaglutide Spray

Semaglutide Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 5 mg, 10 mg, 20 mg, or 30 mg per unit. The formulation is buffered near pH 7.4, where the C18 diacid side chain keeps the analogue soluble without organic co-solvent. Headspace is nitrogen-purged before capping to protect the Trp31 indole ring from oxidation, and no reconstitution step is required.

Store Semaglutide Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Do not freeze: acylated GLP-1 analogues self-associate into oligomers at the ice interface, and repeated freeze-thaw cycles seed beta-sheet fibrils that no filtration step reverses. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

Semaglutide is a selective agonist at the glucagon-like peptide-1 receptor (GLP-1R, UniProt P43220), a class B1 G protein-coupled receptor, and it engages no other incretin receptor. Binding drives Gαs coupling to adenylyl cyclase, raising cAMP and activating both PKA and Epac2, which closes ATP-sensitive potassium channels, opens voltage-gated Ca²⁺ channels, and triggers glucose-dependent insulin granule exocytosis (KEGG hsa04911). Three engineered changes define the molecule: an Aib8 substitution that blocks DPP-4 cleavage, a Lys34→Arg swap that confines acylation to Lys26, and a γGlu-2×AEEA-linked C18 diacid that binds serum albumin. Unlike Tirzepatide, which also activates GIPR, Semaglutide is a balanced GLP-1R-selective agonist.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary metabolic research compounds such as Cagrilintide. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the oxidation-sensitive Trp31 residue and guard the peptide backbone against aggregation. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.