Sermorelin Spray

Sermorelin Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 10 mg or 20 mg per unit. At 29 residues it sits in a comfortable middle range for solubility, dissolving cleanly in aqueous buffer without an organic co-solvent. Headspace is nitrogen-purged before capping to protect the methionine residue, and no reconstitution step is required.

Store Sermorelin Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Do not freeze: repeated freeze-thaw cycles accelerate both methionine oxidation and deamidation, and this sequence lacks the N-terminal protection that stabilizes Tesamorelin, so it is the more fragile of the two GHRH analogs. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

Sermorelin is the first 29 residues of growth hormone-releasing hormone, and that truncation is the whole point: laboratory investigations established that this fragment retains essentially all the receptor activity of the full 44-residue hormone, making it the minimal active sequence. It binds the GHRH receptor on pituitary somatotroph cells, which couples to adenylyl cyclase, raises cAMP and activates protein kinase A, driving growth hormone gene transcription through CREB and Pit-1. What separates Sermorelin from Tesamorelin is not the receptor but the stability. Sermorelin carries no N-terminal protecting group, so it is cleaved rapidly by the same aminopeptidase that Tesamorelin resists, which makes the pair a clean way to isolate enzymatic stability from receptor pharmacology.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary growth factor research compounds such as Ipamorelin. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the single methionine residue and the asparagine positions prone to deamidation. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.