Thymosin Alpha-1 Spray

Thymosin Alpha-1 Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 10 mg per unit. This peptide is unusually water-soluble — it is rich in acidic residues and carries no cysteines — so it dissolves cleanly in aqueous buffer without any organic co-solvent. Headspace is nitrogen-purged before capping, and no reconstitution step is required.

Store Thymosin Alpha-1 Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Avoid freeze-thaw cycling: while this peptide has no disulfide bonds to scramble, repeated cycling accelerates deamidation at the C-terminal asparagine. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

Thymosin Alpha-1 is a 28-amino-acid fragment of prothymosin alpha that acts on innate immune receptors rather than a hormone receptor. Research shows it engages Toll-like receptor 2 and Toll-like receptor 9 on dendritic cells and monocytes, signaling through the MyD88 adaptor into NF-κB and interferon regulatory factor pathways. Romani and colleagues established that dendritic cell activation and Th1 polarization depend on this Toll-like receptor route, with interleukin-12 output as the readout. Downstream, laboratory investigations describe thymocyte maturation, shifts in CD4 and CD8 populations, and increased natural killer cell activity. A 2017 Nature Medicine report added a second, unrelated activity: modulation of cellular protein quality control.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary immune research compounds such as KPV or LL-37. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the N-terminal acetyl group and the C-terminal asparagine, the two positions most vulnerable in this sequence. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.