Tirzepatide Spray

Tirzepatide Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 10 mg or 20 mg per unit. The formulation is buffered near pH 7.4, where the C20 fatty diacid side chain keeps the peptide soluble without organic co-solvent. Headspace is nitrogen-purged before capping to limit Trp and Met oxidation, and no reconstitution step is required.

Store Tirzepatide Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Do not freeze: lipidated peptides like Tirzepatide self-associate into micellar aggregates at the ice interface, and repeated freeze-thaw cycles drive irreversible fibrillation that no filtration step recovers. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

Tirzepatide is a unimolecular dual agonist at two class B1 G protein-coupled receptors: the GIP receptor (GIPR, UniProt Q99835) and the GLP-1 receptor (GLP-1R, UniProt P43220). Both couple through Gαs to adenylyl cyclase, raising cAMP and activating PKA and Epac2. What separates Tirzepatide from Semaglutide is imbalance and bias. Willard et al. (2020) showed it behaves as a full agonist at GIPR but only a partial agonist at GLP-1R, and at GLP-1R it is biased toward cAMP generation over β-arrestin recruitment. Reduced β-arrestin coupling means less receptor internalization and slower desensitization. The Lys20 γGlu-2×AEEA-eicosanedioic acid conjugate drives albumin binding rather than receptor contact.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary incretin research compounds such as Cagrilintide. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the oxidation-sensitive Trp25 residue and the peptide backbone against aggregation. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.