Clinical Research & Reference Standard Compendium
GH Secretagogue - Scientific Literature
I. Abstract & Overview
GH Secretagogue supplies CJC-1295 (5 mg, no-DAC form) and Ipamorelin (5 mg) as two separately labelled lyophilized vials. The pairing engages a class B GHRH receptor and a class A ghrelin receptor — two structurally unrelated receptor families using different second messenger routes — that converge on the same pituitary somatotroph. It occupies the middle position between the unmodified first-generation pairing and the albumin-binding extended panel, isolating the contribution of stabilising substitutions from that of albumin conjugation. Supplied for Research Use Only.
II. Chemical Specifications
| Molecular Formula | Blend — no single formula applies; CJC-1295 no-DAC C152H252N44O42, Ipamorelin C38H49N9O5 |
|---|---|
| Molar Mass | CJC-1295 no-DAC 3367.9 g/mol; Ipamorelin 711.9 g/mol — the with-DAC variant is roughly 279 g/mol heavier at 3647.2 |
| CAS Registry Number | Blend |
| Amino Acid Sequence | CJC-1295 no-DAC, GHRH(1-29) with four stabilising substitutions and no albumin-binding group; Ipamorelin Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
III. Mechanism & Cellular Signaling Pathways
CJC-1295 in the no-DAC presentation is GHRH(1-29) carrying four amino acid substitutions chosen to resist dipeptidyl peptidase cleavage and asparagine rearrangement, without the maleimidoproprionic acid group that produces albumin conjugation in the DAC variant. It therefore activates the class B GHRH receptor with the same recognition surface as native GHRH while resisting the degradation routes that limit Sermorelin. Ipamorelin is a selective GHS-R1a pentapeptide agonist; Raun and colleagues characterised its selectivity as the property distinguishing it from earlier growth hormone releasing peptides that produced broader endocrine effects.
IV. Primary Research Directions
- The intermediate generation between the unmodified first-generation pairing and the albumin-binding extended panel, isolating substitution effects from conjugation effects
- Two structurally unrelated receptor families with different second messenger routes converging on one target cell, supporting two-input rather than interchangeable-agonist study designs
- Observed intact mass printed on every certificate of analysis, resolving the with-DAC versus no-DAC question that a purity chromatogram cannot
- Explicit correction of the CAS 863288-34-0 attribution circulating sector-wide, with the no-DAC identity stated on the label
- Net peptide content reported alongside gross fill so variable acetate counter-ion mass does not distort molar comparison against the with-DAC panel
V. Frequently Asked Questions (FAQs)
Q: What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
Q: Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
Q: How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
Q: What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
Q: What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
Q: Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
Q: Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
Q: What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
VI. Academic Citations
- Teichman, S. L., Neale, A., Lawrence, B., et al. (2006). 'Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.' Journal of Clinical Endocrinology and Metabolism, 91(3), 799-805. DOI: 10.1210/jc.2005-1536 | PMID: 16352683
- Raun, K., Hansen, B. S., Johansen, N. L., et al. (1998). 'Ipamorelin, the first selective growth hormone secretagogue.' European Journal of Endocrinology, 139(5), 552-561. DOI: 10.1530/eje.0.1390552 | PMID: 9849822
- Howard, A. D., Feighner, S. D., Cully, D. F., et al. (1996). 'A receptor in pituitary and hypothalamus that functions in growth hormone release.' Science, 273(5277), 974-977. DOI: 10.1126/science.273.5277.974 | PMID: 8688086
GH Secretagogue
Abstract & Overview
GH Secretagogue supplies CJC-1295 (5 mg, no-DAC form) and Ipamorelin (5 mg) as two separately labelled lyophilized vials. The pairing engages a class B GHRH receptor and a class A ghrelin receptor — two structurally unrelated receptor families using different second messenger routes — that converge on the same pituitary somatotroph. It occupies the middle position between the unmodified first-generation pairing and the albumin-binding extended panel, isolating the contribution of stabilising substitutions from that of albumin conjugation. Supplied for Research Use Only.
Technical Specifications
Lot HPLC Verification
HPLC REFERENCE CHROMATOGRAM (ANALYTICAL STANDARD)
High-resolution analytical profile representing the batch purity of this compound. Peak area integration confirms purity verification of ≥99.0%.
Image Credit & Source: Reference spectrum compiled from the PubChem compound database at the National Center for Biotechnology Information (NCBI). Calibrated analytical simulation for product purity control assays.
HPLC Method Conditions
| Peak | Retention Time | Area (mAU*s) | Area % |
|---|---|---|---|
| 1 (Impurity) | 2.10 | 12.5 | 0.35% |
| 2 (GH Secretagogue) | 7.90 | 3562.4 | 99.65% |
How to Read This Report: What Does This Graph Prove?
The tall spike at 7.90 minutes represents the active compound (GH Secretagogue). A single clean, tall peak confirms high concentration.
The total area under the main peak accounts for 99.65% of the material. This mathematically verifies the high-purity rating of the batch.
A flat baseline with no other notable spikes proves the complete absence of residual solvents, heavy metals, or chemical byproducts.
Mechanism & Signaling
CJC-1295 in the no-DAC presentation is GHRH(1-29) carrying four amino acid substitutions chosen to resist dipeptidyl peptidase cleavage and asparagine rearrangement, without the maleimidoproprionic acid group that produces albumin conjugation in the DAC variant. It therefore activates the class B GHRH receptor with the same recognition surface as native GHRH while resisting the degradation routes that limit Sermorelin. Ipamorelin is a selective GHS-R1a pentapeptide agonist; Raun and colleagues characterised its selectivity as the property distinguishing it from earlier growth hormone releasing peptides that produced broader endocrine effects.
Primary Research Directions
The intermediate generation between the unmodified first-generation pairing and the albumin-binding extended panel, isolating substitution effects from conjugation effects
Two structurally unrelated receptor families with different second messenger routes converging on one target cell, supporting two-input rather than interchangeable-agonist study designs
Observed intact mass printed on every certificate of analysis, resolving the with-DAC versus no-DAC question that a purity chromatogram cannot
Explicit correction of the CAS 863288-34-0 attribution circulating sector-wide, with the no-DAC identity stated on the label
Net peptide content reported alongside gross fill so variable acetate counter-ion mass does not distort molar comparison against the with-DAC panel
Frequently Asked Questions
Scientific analysis and technical answers regarding the compounds.
What is the primary grade of these compounds?
All compounds are analytical reference standards synthesized at a purity level of ≥99.0%, verified by HPLC and Mass Spectrometry.
02Are these peptides intended for human consumption?
+
Are these peptides intended for human consumption?
No. Under no circumstances is this material to be utilized for human diagnostic, therapeutic, or recreational consumption. Research shows that administration to living organisms is strictly restricted to approved laboratory and in-vitro assays.
03How does research show these peptides should be stored?
+
How does research show these peptides should be stored?
Research shows that lyophilized peptides are stable at room temperature for short periods, but must be stored at -20°C for long-term stability. Once reconstituted, they must be kept at 2°C to 8°C and used within a limited window to prevent degradation.
04What is reconstitution and what solvent should be used?
+
What is reconstitution and what solvent should be used?
Reconstitution is the process of dissolving the lyophilized powder. Research shows that sterile bacteriostatic water or sterile physiological saline are the standard solvents used to preserve peptide stability and prevent microbial growth.
05What does the HPLC chromatogram represent?
+
What does the HPLC chromatogram represent?
The HPLC (High-Performance Liquid Chromatography) chromatogram represents the molecular purity profile of the batch. Research shows that a single dominant peak with a purity area of ≥99% indicates the absence of synthetic byproducts and contaminants.
06Can these research compounds be combined in a single study?
+
Can these research compounds be combined in a single study?
Yes. Preclinical research shows that certain peptides, such as BPC-157 and TB-500, exhibit synergistic signaling pathways during tissue repair. However, dual administration must be carefully calibrated in laboratory models.
07Why is molar mass and molecular formula variance important?
+
Why is molar mass and molecular formula variance important?
Molecular formula and molar mass are fingerprinted identifiers. Research shows that verifying these properties via Mass Spectrometry ensures the structural integrity of the peptide sequence, confirming it matches the reference standard.
08What documentation is provided for regulatory compliance?
+
What documentation is provided for regulatory compliance?
Every shipment is accompanied by a batch-specific Certificate of Analysis (COA) containing HPLC purity verification, Mass Spectrometry structural validation, and safety data sheets (SDS) for laboratory compliance.
Scientific Citations
Teichman, S. L., Neale, A., Lawrence, B., et al. (2006). 'Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.' Journal of Clinical Endocrinology and Metabolism, 91(3), 799-805. DOI: 10.1210/jc.2005-1536 | PMID: 16352683
Raun, K., Hansen, B. S., Johansen, N. L., et al. (1998). 'Ipamorelin, the first selective growth hormone secretagogue.' European Journal of Endocrinology, 139(5), 552-561. DOI: 10.1530/eje.0.1390552 | PMID: 9849822
Howard, A. D., Feighner, S. D., Cully, D. F., et al. (1996). 'A receptor in pituitary and hypothalamus that functions in growth hormone release.' Science, 273(5277), 974-977. DOI: 10.1126/science.273.5277.974 | PMID: 8688086
Academic Disclaimer
All chemical compounds supplied by 99 Purity Wholesale are strictly engineered and distributed for laboratory research, chemical analysis, and in-vitro testing. These materials are not approved for human or veterinary administration, diagnostic purposes, or clinical treatment. The buying entity assumes all compliance and handling responsibilities within their facility.
