IGF-1 LR3 Spray

IGF-1 LR3 Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 1 mg per unit. The low unit strength reflects real usage, since receptor assays work at nanomolar concentrations rather than the milligram loads metabolic compounds need. At 83 residues this is a folded protein rather than a short peptide, and the buffered pre-dissolved format avoids the harsh acidic reconstitution that powder forms of this analogue usually require. Headspace is nitrogen-purged before capping.

Store IGF-1 LR3 Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Never freeze this one. As a folded 83-residue protein it loses activity through denaturation and disulfide scrambling rather than through simple chemical degradation, and a single freeze-thaw cycle can unfold material that still gives the correct mass on analysis. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

IGF-1 LR3 activates the IGF-1 receptor, a receptor tyrosine kinase rather than a G protein-coupled receptor, which changes both the signaling and the assay readouts entirely. Ligand binding triggers receptor autophosphorylation, recruitment of insulin receptor substrate proteins, and activation of two downstream branches: the PI3K and Akt axis governing survival and protein synthesis, and the MAPK cascade governing proliferation. The engineering is what distinguishes this analogue. Native IGF-1 circulates almost entirely bound to binding proteins that sequester it; substituting arginine for glutamate at the third position disrupts that binding, and a 13-residue amino-terminal extension adds further. Tomas and colleagues showed variants that bind those proteins poorly are more potent and longer-acting.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary growth factor research compounds such as Ipamorelin. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the three disulfide bonds that hold the folded structure together. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.