Kisspeptin Spray

Kisspeptin Spray is supplied as a pre-dissolved, sterile-filtered solution in amber glass bottles fitted with a metered atomizer, at 10 mg per unit. The sequence carries two tryptophan-adjacent aromatic residues and a free tyrosine, so amber glass earns its place against photodegradation. Headspace is nitrogen-purged before capping, and no reconstitution step is required.

Store Kisspeptin Spray refrigerated at 2°C to 8°C (36°F to 46°F), upright and protected from light, where sealed units remain within specification for up to 24 months. Once the atomizer is first actuated, use the unit within 30 days. Avoid freeze-thaw cycling, which accelerates both tryptophan oxidation and hydrolysis of the C-terminal amide, and it is the amide loss that matters most here because it silently converts active peptide into inactive free acid. Brief transit excursions to 15°C to 25°C (59°F to 77°F) are tolerated.

Kisspeptin-10 activates KISS1R, a G protein-coupled receptor expressed on hypothalamic neurons, and its position in the hierarchy is what makes it distinctive. Receptor activation couples through Gq to phospholipase C, generating inositol trisphosphate and diacylglycerol, releasing intracellular calcium and depolarizing the neuron. Those neurons then release gonadotropin-releasing hormone, which drives pituitary output. In other words this peptide sits one level above GnRH, acting as the upstream trigger rather than a GnRH analog, which is precisely why it can distinguish a hypothalamic defect from a pituitary one. Kotani and colleagues identified kisspeptins as the natural ligands of this receptor, and independent groups later showed that losing receptor function blocks the onset of puberty.

Yes. Qualified procurement partners can request alternative concentrations, non-standard bottle volumes, unlabeled or private-label presentation, or co-formulation with complementary neuroendocrine research compounds. Contact our corporate sales desk with your target concentration and unit count to scope the run.

Units ship in light-blocking, vacuum-sealed secondary packaging with temperature-stability buffers that hold the shipment inside the refrigerated range through transit. Amber primary containers and nitrogen-purged headspace protect the C-terminal amide required for receptor activation. We ship nationwide across all 50 US states and internationally via express couriers with discrete, border-optimized clearance and full delivery assurance.